Berdazimer Gel: A Breakthrough Treatment for Molluscum Contagiosum (MC)

• Generic Name : Berdazimer
• Brand Name: Zelsuvmi
• Drug Type: Topical Nitric Oxide Releasing Agent
• FDA Status: Novel Drug Designation (2024)

Introduction to Berdazimer Gel :

• Molluscum contagiosum (MC) is a common and contagious skin disease caused by a poxvirus. It primarily affects children, although adults can also get it. Until recently, treatment options were limited, painful, or ineffective.
• The FDA approved Berdazimer Gel 10.3% under the brand name Zelsuvmi in 2024, a revolutionary step forward in managing MC in a safe and non-invasive way. In this blog post, we explore everything you need to know about Berdazimer Gel – its uses, mechanism of action, clinical trial results, side effects, usage patterns, and safety profile.

What Is Berdazimer ?

Berdazimer is a topical medication that was approved by the US FDA in 2024 for the treatment of molluscum contagiosum in patients 1 year of age and older. It is formulated at a 10.3% strength and is the first nitric oxide-releasing gel of its kind for this indication.

What is Molluscum contagiosum ?

Molluscum contagiosum is a common and usually harmless skin infection caused by the molluscum contagiosum virus (MCV), a member of the poxvirus family. It primarily affects children but can also occur in adults, especially those with weakened immune systems or those in close physical contact, such as athletes. The infection causes small, smooth, dome-shaped bumps on the skin that are usually flesh-colored or pink with a characteristic central dimple. These lesions are usually painless, although they may itch or swell.

Molluscum contagiosum is spread through direct skin-to-skin contact, contact with contaminated objects such as towels or clothing, or through sexual contact in adults. Although the condition often clears up on its own within 6 to 12 months without scarring, treatment may be attempted to prevent spread or for cosmetic reasons. Options include cryotherapy, curettage, and newly approved topical treatments such as Berdazimer gel, which offers painless and effective relief for adults and children.

Mechanism of Action :

The active component in Berdazimer gel releases nitric oxide (NO) upon application to the skin. Nitric oxide is a natural molecule with antiviral, antibacterial, and immunomodulatory properties. Here’s how it works:

• Antiviral Activity: NO inhibits viral replication by modifying viral proteins.
• Immune Activation: NO enhances the skin’s immune response to target the molluscum virus.
• Targeted Action: Because it’s topical, it minimizes systemic exposure.

This dual-action—direct antiviral effect and immune support—makes Berdazimer gel especially effective in eradicating MC lesions.

Who Can Use Berdazimer Gel?

Berdazimer gel is approved for use in both adults and children aged 1 year and older. It is especially beneficial for:

• Children with widespread or persistent MC
• Adults with immunocompromised skin
• Patients seeking non-invasive and pain-free treatment

Clinical Trials and FDA Approval :

Efficacy Results –

The approval of Berdazimer was based on pivotal Phase 3 trials involving over 800 patients. Key findings include:

• 70% lesion clearance after 12 weeks of once-daily use
• Statistically significant improvement compared to placebo
• Visible improvement as early as week 4

Safety Profile –

• Mild to moderate side effects
• Most common: redness, stinging, itching at application site
• No systemic side effects or toxicity reported

These results made Berdazimer gel the first and only FDA-approved topical treatment for molluscum contagiosum.

How to Apply Berdazimer Gel :

Application is simple and painless:

1. Wash and dry the affected area.
2. Apply a thin layer of Berdazimer gel (Zelsuvmi) once daily.
3. Do not cover with a bandage unless advised.
4. Continue treatment for up to 12 weeks, or until lesions clear.

Important: Avoid contact with eyes, mouth, or broken skin.

Benefits :

✅ Pain-Free: Unlike cryotherapy or curettage
✅ Pediatric-Friendly: Approved for children as young as 1
✅ At-Home Use: No need for clinic visits
✅ Proven Efficacy: High success rate in clinical trials
✅ Minimal Side Effects: Well-tolerated by all age groups

Potential Side Effects of Berdazimer Gel :

Though generally safe, some users may experience:

• Mild erythema (redness)
• Itching or burning sensation
• Localized dryness or peeling

These effects are usually temporary and do not require discontinuation.

Storage and Handling :

• Store Berdazimer gel at 20–25°C (68–77°F)
• Keep the tube tightly closed
• Do not freeze
• Keep out of reach of children

Cost and Availability :

As of 2025, Zelsuvmi (Berdazimer gel) is available by prescription in most U.S. pharmacies. The manufacturer may offer discount cards or co-pay assistance programs. Always consult your dermatologist or pediatrician before starting the treatment.

Conclusion :

Berdazimer Gel (Zelsuvmi) is a game-changing treatment for molluscum contagiosum, especially in pediatrics. Its ability to safely and effectively clear lesions without pain or invasive procedures makes it an extremely valuable tool in dermatology. With its novel nitric oxide-based mechanism, Berdazimer Gel not only treats but also prevents recurrence, giving new hope to the millions of people affected by this viral skin condition.

If you or your child is struggling with molluscum contagiosum, talk to your healthcare provider today about the benefits of Berdazimer Gel.

Frequently Asked Questions (FAQs)

Disclaimer: This blog post is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making any medical decisions.