1. What is rucaparib mechanism of action?

Rucaparib mechanism of action involves inhibition of PARP enzymes, leading to impaired DNA repair and cancer cell death in BRCA-mutated tumors.

2. Why is rucaparib effective in BRCA-mutated cancers?

Because BRCA-mutated cells lack homologous recombination repair, PARP inhibition creates synthetic lethality.

3. What are the common side effects?

Common side effects include anemia, nausea, fatigue, and elevated liver enzymes.

4. When was rucaparib approved by the FDA?

On December 17, 2025 Rucaparib received FDA approval for specific ovarian cancer indications based on clinical trial evidence.

5. Can rucaparib interact with other drugs?

Yes, especially with CYP enzyme inhibitors or inducers.

6. Is rucaparib used as maintenance therapy?

Yes, it is commonly used as maintenance therapy in recurrent ovarian cancer following chemotherapy response.

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