Yartemlea (narsoplimab‑wuug) is the first FDA‑approved treatment for transplant‑associated thrombotic microangiopathy (TA‑TMA).

2.Why is the Yartemlea FDA approval important?

It provides the first targeted therapy for a life‑threatening condition with historically high mortality and no prior approved treatments.

3.How does Yartemlea work?

It inhibits MASP‑2, blocking the lectin complement pathway responsible for endothelial damage in TA‑TMA.

4.What are the main safety concerns?

The most serious risk is infection; patients require close monitoring during treatment.

5.Does Yartemlea have major drug interactions?

No significant CYP450‑related interactions are expected, making it suitable for complex transplant regimens.

6.What complement pathway does Yartemlea target?

Yartemlea selectively targets the lectin pathway of the complement system.

7.Does Yartemlea suppress the entire immune system?

No. It preserves the classical and alternative complement pathways, allowing immune defense to remain functional.

8.Why is MASP-2 inhibition important in TA-TMA?

MASP-2 drives endothelial injury and microvascular thrombosis, the core pathology of TA-TMA.

9.Is Yartemlea used before or after stem cell transplant?

Yartemlea is used after HSCT once TA-TMA is diagnosed.

10.Is Yartemlea effective in pediatric patients?

Yes. The Yartemlea FDA approval includes children aged 2 years and older .

11.Does Yartemlea prevent organ failure in TA-TMA?

By stopping endothelial damage and clot formation, Yartemlea helps protect vital organs .

12.How is Yartemlea different from supportive care?

Supportive care manages symptoms, while Yartemlea targets the disease mechanism itself .

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