Brand Name : Veozah for menopause
Generic Name : fezolinetant
Category : Miscellaneous central nervous system agents
Forms : tablets for oral use .
Table of Contents
What is Veozah for menopause tablet ?
A prescription drug called Veozah (fezolinetant) has been approved to treat moderate to severe vasomotor symptoms (VMS) related to menopause, which include hot flashes and night sweats. Veozah is a non-hormonal alternative to hormone replacement treatments that functions by inhibiting a particular brain receptor known as neurokinin 3 (NK3), which is essential for controlling body temperature. Veozah, which was approved by the FDA in May 2023, provides a novel therapy option for menopausal women who are unable or unable to use hormonal medications.

How veozah tablet works ?
The hormone estrogen starts to decrease in a woman’s body when she undergoes menopause. Numerous bodily systems are impacted by this sudden decrease, especially the brain’s temperature regulation system. This explains why vasomotor symptoms (VMS), such as hot flashes and at night sweats, are common in women going through menopause.
The hypothalamus is a small region inside the brain that regulates body temperature.A unique subset of brain cells known as KNDy neurons becomes overactive during menopause as a result of decreased estrogen.
The body receives wrong signals from these hyperactive neurons, giving a signal that it is overheating when actually it is not. This results in hot flashes, which are sudden episodes of sweating, redness, and heat. Fezolinetant is the active ingredient in Veozah.Were’s where Veozah for menopause helps:
• KNDy neurons are unique nerve cells found in the brain that transmit signals that impact the body’s regulation of body temperature.
• These neurons become hyperactive when estrogen levels drop, which makes you feel heated when you’re not.
• Veozah inhibits the neurokinin-3 receptor (NK3R), a particular receptor on these neurons.
Veozah reduces the activity of these hyperactive neurons by inhibiting NK3R.
• As a result, symptoms like hot flushes and night sweats decrease and the brain regains better control over body temperature.
The fact that Veozah is a non-hormonal treatment—that is, it doesn’t include progesterone or estrogen—makes it an excellent choice for women who are unwilling or unable to undergo hormone therapy.
How Veozah is safer from other Hormonal drugs like premarin, Estrace, Climara & Activella ?
- On the other hand, conventional hormonal medications like as Estrace (estradiol), Climara (estradiol patch), Activella (estradiol + norethindrone), and Premarin (conjugated estrogens) function by substituting the estrogen that the body stops producing following menopause.
- These medications help prevent bone loss, treat mood swings, vaginal dryness, and hot flashes. However, blood clots, breast cancer, stroke, and heart disease are among the hazards associated with hormone replacement treatment (HRT), particularly for women who have a personal or family history of these disorders.
A new non-hormonal medication called Veozah (fezolinetant) has been approved to treat menopausal women’s mild to severe vasomotor symptoms, such as hot flashes and night sweats. - Veozah provides a safer option for treating hot flashes and night sweats on its own by blocking neurokinin-3 (NK3) receptors in the brain, particularly for women seeking a non-hormonal treatment. A novel approach to menopausal care is shown in this targeted, brain-based treatment.
What is veozah used to treat ?
1.Treatment of Vasomotor Symptoms (VMS):
Veozah is mainly used to treat menopausal hot flashes and night sweats that range from moderate to severe. Changes in hormone levels that impact the ability of the brain to control body temperature are an origin of these symptoms.
2. Non-Hormonal Option for Menopause Relief:
For women who are not allowed or able to take hormone replacement therapy (HRT) because of health hazards such as heart disease, blood clots, or breast cancer, Veozah can be especially beneficial.
3.Improves Quality of Life During Menopause:
Veozah helps menopausal women in improving their comfort, quality of sleep, and ability to operate on a daily basis by lowering the frequency and severity of hot flashes.
Dosage of Veozah for Menopause :
Recommended Dose:
The typical dose of Veozahfor menopause is 45 mg taken once daily by mouth.
How to Take It:
- Take the tablet at the same time each day, with or without food.
- Swallow the tablet whole with water.
- Do not crush, chew, or split the tablet.
- If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed one—do not double the dose.
Important:
Liver function tests should be done before starting treatment and regularly during use (e.g., at 1, 2, 3, 6, and 9 months) due to rare risk of liver injury.
Storage Conditions for Veozah for menopause :
Store at room temperature:
Keep between 20°C to 25°C (68°F to 77°F).
Keep away from:
- Moisture
- Heat
- Direct sunlight
Keep out of reach of children and pets.
Do not use expired medicine. Check the label for the expiry date.
Side Effects of Veozah :
1.Common Side Effects of Veozah:
These are usually mild and may go away as your body adjusts to the medicine:
- Headache
- Stomach pain or abdominal discomfort
- Diarrhea
- Trouble sleeping (insomnia)
- Back pain
- Hot flushes (in some cases)
- Elevated liver enzymes (found in blood tests)
2.Serious Side Effects of Veozah:
Although rare, some side effects may require medical attention:
Liver injury:
Veozah for menopause can cause liver problems in rare cases. Signs include:
- Yellowing of the skin or eyes (jaundice)
- Dark urine
- Loss of appetiteNausea or vomiting
- Fatigue
Allergic reactions (rare):
- Rash
- Itching or swelling (especially of the face, tongue, or throat)
- Severe dizziness
- Trouble breathing
Who Should Avoid Veozah for menopause ?
Although Veozah (fezolinetant) generally is well tolerated, certain individuals shouldn’t take it due to safety risks. Consultation with a physician is essential prior to beginning treatment. The main groups that should be avoided or use caution are listed below:
1. Women with Liver Problems :
- Do not take Veozah for menopause if you have severe liver disease.
- Veozah can have an impact on liver function, and those who already have liver problems may be at greater risk to severe liver damage.
- Before beginning treatment and throughout it, liver tests are essential.
2. People with Allergies to Fezolinetant :
- Avoid using Veozah if you already have had an allergic reaction to the fezolinetant or any of its ingredients.
- Rashes, swelling, dyspnea, or drowsiness are signs of an allergy.
3. Pregnant or Breastfeeding Women :
- Veozah is only licensed for postmenopausal women.
- It is not meant for use during pregnancy.
- Its safety in mothers who are breastfeeding has not been proven, it is generally advised to avoid using it.
4. Women Taking Certain Medications :
- Strong CYP1A2 inhibitors, such as fluvoxamine, shouldn’t be taken with Veozah as they may increase the drug’s level in your body and increase the risk of adverse effects.
- Always inform your doctor about all of the drugs and supplements you’re taking.
Conclusion :
Veozah (fezolinetant) is an important improvement in the management of hot flashes and at night sweats associated with menopause. For women who are not able to take hormone replacement treatment, this non-hormonal, once-daily oral tablet gives comfort. Veozah enhances quality of life and helps regain temperature regulation by focusing on the brain’s neurokinin-3 receptors during menopause .
Even though it is usually well tolerated, safety must be ensured by routine liver monitoring. It should only be taken under a doctor’s supervision because, like all medications, it may have adverse effects.
Veozah is a promising and efficient treatment for vasomotor symptoms that is supported by clinical research and FDA approval for women looking for a modern, hormone-free alternative.